Prime Evil entführt Madame Vai. So will er ihre Ghostbuster-Freunde in die Falle locken. Doch er hat nicht mit deren Freunden Jessica, Futura und Belfey gerechnet.
Madam Why receives a gift that turns out to be from Prime Evil and spirits her away as his captive in Hauntquaters. Using her as bait he captures the Ghostbusters, so its up Futura and Jessica to save the day.