The "Three Brainiacs" in question are Chemist Marie Curie, Pasteurization Inventor Louis Pasteur, and general all-around smart guy Albert Einstein.
Spydra realizes she needs a scientist with a bit more...practical experience than Boris to build her Super Spydra Clone.
(Marie Curie, 1902, Paris, France, Louis Pasteur, 1864, Paris France & Albert Einstein, 1932, New York City, New York)