Mike is pushed nearly over the edge by his pressing partners, a girlfriend who wants to move, a missing patient and the pressure of promoting his first novel, Panacea.
Mike has problems reconciling his medical methods, such as house calls, with his father and his partners, which puts his part of the partnership in critical condition.
Mike's novel gets rave reviews, but doesn't sell and his first day as a TV doctor is marred by an incident involving a jelly doughnut and the Heimleich maneuver. Mike's try at a practicing on his own gets a slow start.
While having a heart attack, Mike's landlord persuades him to buy the house his apartment is in. Mike's TV career continues to get a shaky start as well getting back with the partners.
As a favor to Dierdre, Mike makes a house call to a cantankerous patient, who turns out to be her bitter father. Grant makes an appearance with Mike on Wake Up Providence....
Her shot as a nurse in Mike's office, Mike's mother responds well, but the arrangement has a bad effect on his father, who wants her back at home.
Mike looks after Abe's son for a weekend and helps to rewrite some important laws that Abe had lain down. Grant looks to find a family for Yom Kippur.
Grant discovers that his membership into an exclusive country club proves to be ""exclusive"" in a colorless way.
""Rex, the Hound From Hell"", defeats Abe and Dierdre offers to whip him into shape. Mike refers an elderly heart patient to Grant and the man bypasses Mike's advice and goes with the surgery Grant recommends, but he doesn't make it.
Being listed as the 4th most eligible bachelor in Providence makes Mike a sudden winner in the dating game, but a loser with his girlfriend and the partnership.
Against advice and his better judgment, Mike has the hots for a jet-setting photographer he has just treated for malaria and she has the hots for him. Abe needs to lose ten pounds for an insurance physical.
Mike's gay brother Richard helps Grant write a speech and the two become close friends, but maybe too close for the comfort of Mike, Dierdre and Abe.
After learning that an old acquaintance is coming to visit, the partners recall their first meeting with a really weird guy named Mike when they were med students.
Dierdre has an overly negative reaction to a patient who tells her he's HIV-positive.
Abe thinks he's having marriage problems, but in truth his wife has a problem she fears will disrupt his ""perfect"" life; Dierdre becomes a biker's dream chick.
Mike's Aunt Laura, a high-profile plastic surgeon, has a base attraction to Grant, and Grant considers leaving the partnership to join hers.
Mike looks for adoptive parents for a young woman's unborn child, until Dierdre arranges to make herself the mommy.
Mike and Dierdre have a double-date disaster when Dierdre's guy turns out to be the estranged husband of Mike's girl.
Mike's TV career bites the dust after he refuses to let a quack doctor with a powder-diet treatment eat up half of his air time; Abe tries painting, with unpalatable results.
Mike gets a hernia while lifting weights on the morning show, but like any doctor the thought of having surgery is utterly unthinkable, so he tries to put it off by leaving the surgery.
Mike finds a woman attractive that Grant says he is ready to break up with. He moves in a little too early, before the official breakup and this puts a strain on their friendship and the partnership, when Grant changes his mind. Abe has nothing but problems with the car Dierdre sold him, so she offers to buy it back.
Mike is against it when the other partners decide to make some changes that will increase business; he feels the patients will lose in the end and one almost does.
Mike may be an accomplice to murder when he tells a mystery writer about an undetectable poison, later he discovers that her husband has died under mysterious circumstances. Dierdre lets Justin's mouse of its cage.
Mike goes on a ""date from hell"" with Grant's sister, a psychiatrist who moves in from Chicago, and unloads some emotional baggage she's been carrying since her marriage fell apart. The Butterfield's try for another baby.
Dierdre falls in love with a wealthy man whom the partners join on a trip to Key West in his private plane. Something goes wrong mid-flight when he has a heart attack while she is keeping him ""company"" in the cockpit. Abe isn't comfortable with the fact he needs glasses.
Mike is supposed to fire Leona's new assistant, who's driving everyone crazy, but when he tries, the assistant meets Richard and the two hit it off. Later, Richard pressures Mike to get the job back, which he does. Then Richard finds out what he is really like.
Mike is stuck being on call during the weekend his father is being honored by the Medical Association. When Richard isn't invited, Mike wants to patch things up between them; however, his father is involved in a life-threatening accident.
Richard suggests that Mike start a reading group to keep his ""brain alive."" When everyone has left the room, things get strange when Mike and Leona are left alone in his apartment.
Grant has an opportunity to do some hand modeling work, but becomes over protective of his hands. Mike finds himself treading lightly after he apparently injures Abe's son, the star player of a ""pee-wee"" hockey team, while practicing before the big game.
Mike decides the new receptionist is not working out when her involvement with Grant interferes with the practice or is it their age difference?
Abe finds out the reason he and Gail can't have another child is caused by his low sperm count. The partners are participating in the making of a Japanese documentary on American medicine. Mike prescribes some medication for a woman, not knowing she is taking something that will react with it. Consequently, she winds up in the hospital and he is handed a lawsuit.
Abe must wait ten days before he gets his sperm count retested. Mike is ambushed on Wake Up Providence... by the opposition in his legal trouble. When his patients, friends and his lawyer are abandoning him, Mike is faced with an out-of-court settlement that he reluctantly agrees to.
After quitting the practice, Mike moves to a cabin in the mountains. The partners miss Mike, but Grant feels they need to interview for a replacement. Mike begins to treat the local yokels. The partners go to the mountains to bring him back.
Excerpts from Mike's new novel don't shed a good light on the other partners, so they try to block it by getting a court order stopping the publication. Mike works on their egos as he tries to get them to remove the injunction.
Richard gets hooked on sleeping pills and the partners realize they've all been used to feed his habit. So Mike needs to the partners need to keep an eye on him until he falls asleep which puts a damper on their trip to New York.
Mike tries to rekindle his romance with Jenna, the jet-setting photographer, but her latest exhibition shows him in all his glory. Abe lets Dierdre & Faye in on a winning proposition, but not Grant.
Mike makes the plans for Abe and Gail's wedding anniversary at the dorm room where they first met, but Gail has other ideas. Abe winds up staying at Mike's.
Mike thinks it's time for Abe to get out again, it's been three months since Abe and Gail separated, so Mike finds him a blind date.
Mike & Richard ask their father for a loan to fix their leaky roof, then they stumble across his dirty laundry and try to figure out it is for real. Faye dumps her companion of twelve years.
Dierdre's patient dies; she is shaken by the event and fearful that she will grow old alone. In his effort to help, Mike offers to marry her.
