Her kan du møde 10-årige Piet, som har en sygdom så sjælden, at læger over hele verden ikke har kunnet stille en diagnose. Andrea på 12, hvis stofskiftesygdom er så alvorlig, at hun skal have behandling hver uge for at overleve. Og Bastian på otte, hvis Crouzon-syndrom gør, at han skal igennem utallige kranieoperationer. Men på trods af et liv ind og ud af hospitalet, og en hverdag med mange udfordringer, insisterer Piet, Andrea og Bastian på at få det bedste ud af livet. At gå til fodbold og være sammen med gode venner, som holder humøret oppe mellem de mange hospitalsbesøg.
Here you can meet 10-year-old Piet, who has a disease so rare that doctors all over the world have not been able to diagnose it. Andrea, 12, whose metabolic disease is so severe that she must have treatment every week to survive. And Bastian, eight, whose Crouzon syndrome means he has to go through countless cranial surgeries. But despite a life in and out of hospital, and an everyday life with many challenges, Piet, Andrea and Bastian insist on getting the best out of life. Going to football and being with good friends who keep the spirits up between the many hospital visits.