Dannys Erzfeind Vlad ist zurück – und seine Laune ist sogar noch schlechter als sonst: Er wurde nämlich von einer besonders schlimmen Form von Ekto-Akne befallen. Damit Danny ihm hilft, die Krankheit loszuwerden, infiziert Vlad kurzerhand Sam und Tuck mit der tückischen Pickelplage…
Vlad is back, only now he's afflicted with a serious case of ecto-acne, a direct result of the college lab accident with Jack and Maddie. To ensure Danny helps him find a cure, Vlad infects Sam and Tucker with his disease, and Danny turns to Clockwork for help. Danny convinces Clockwork to let him go back in time to make sure the accident that injures Vlad never happens. Unfortunately, when he changes the past, he changes the present. When he arrives back in the present day, Maddie is married to Vlad and living in Wisconsin, and Jack's a ghost named Jack Plasmius! Now, Danny must go back in time for a second time to ensure his parents get together, but when he does, will that mean ecto-acne doom for Tucker and Sam?
עוד הוריו של דני עושים לו בושות לפני חבריו, מופיע לפתע חבר שלהם מימי המכללה. מסתבר שהוא לקה באקנה-חוצני קטלני. כדי לגרום לדני למצוא תרופה למצבו, מדביק ולאד באקנה את חבריו של דני, סאם וטאקר.
Vlad força Danny a conseguir a ajuda de Clockwork para voltar no tempo para se curar de um caso de Ecto Acne que ele contraiu na juventude.
Cuando Vlad sufre un severo caso de ectoacné, se asegura de recibir la ayuda de Danny infectando a Sam y a Tucker. Para ayudar a sus mejores amigos y a su peor enemigo, le pide a Reloj regresar al pasado para evitar que Vlad obtuviera el ectoacné y a su vez sus poderes fantasmas.
Vlad ha una ricaduta della terribile ecto-acne, che aveva contratto in seguito al vecchio incidente che gli aveva fatto guadagnare anche i suoi poteri.
