The return of the documentary telling remarkable tales of human experience from around the world, beginning with a woman who lives with a rare skin condition. Nusrit `Nelly' Shaheen from Coventry is the oldest known survivor of Harlequin Ichthyosis, which causes the skin to grow 10 times faster than normal. As a result, her skin cracks and appears scaly, and she spends four hours every day scrubbing off layers of dead skin. The film follows Nelly as she goes about her daily routines and as she meets others sufferers, as well as her desperate search for treatment to alleviate her symptoms.