Zach Galifianakis sets off on a road trip to interview celebrities for his talk show and repair his reputation along the way.
| Name | Type | Role | |
|---|---|---|---|
| Scott Aukerman | Writer | ||
| Zach Galifianakis | Writer | ||
| Zach Galifianakis | Host | Self | |
| Phoebe Bridgers | Guest Star | Self | |
| Matthew McConaughey | Guest Star | Self | |
| Benedict Cumberbatch | Guest Star | Self | |
| Hailee Steinfeld | Guest Star | Self | |
| Rashida Jones | Guest Star | Self | |
| Matt Berninger | Guest Star | Self | |
| Keanu Reeves | Guest Star | Self | |
| Will Ferrell | Guest Star | Self | |
| Peter Dinklage | Guest Star | Self | |
| Michael Cera | Guest Star | Self | |
| Brie Larson | Guest Star | Self | |
| Awkwafina | Guest Star | Self | |
| Walter Martin | Guest Star | Self | |
| Paul Rudd | Guest Star | Self | |
| Gal Gadot | Guest Star | Self | |
| Chrissy Teigen | Guest Star | Self | |
| John Legend | Guest Star | Self | |
| Chance the Rapper | Guest Star | Self | |
| Bruce Willis | Guest Star | Self | |
| Jason Schwartzman | Guest Star | Self | |
| Tiffany Haddish | Guest Star | Self | |
| Tessa Thompson | Guest Star | Self | |
| David Letterman | Guest Star | Self | |
| John Cho | Guest Star | Self | |
| Adam Scott | Guest Star | Self | |
| Jon Hamm | Guest Star | Self | |
| Scott Aukerman | Director | ||
| Demi Adejuyigbe | Actor | DJ Fwap | |
| Rekha Shankar | Actor | Gaya | |
| Paul Rust | Actor | Eugene Tennyson | |
| Lauren Lapkus | Actor | Carol Hunch | |
| Mandell Maughan | Actor | Nic Jeffries | |
| Mary Scheer | Actor | Frannie Scheindlin | |
| A.D. Miles | Actor | Michael | |
| Ryan Gaul | Actor | Cameron "Cam" Campbell | |
| Mary Holland | Actor | Gerri Plop | |
| Blake Clark | Actor | Earl Canderton | |
| Jiavani | Actor | "Boom Boom" De Laurentis | |
| Matt Besser | Actor | Mike Burcho | |
| Paul F. Tompkins | Actor | Burnt Millipede | |
| Edi Patterson | Actor | Shirl Clarts | |
| Phil Hendrie | Actor | Bill Yum |