In the early 18th century, Antonio Vivaldi composed music for La Pieta in Venice, a home for children who were abandoned at birth. The institution had its own all-female orchestra and choir who provided entertainment in the church for visiting tourists. This film tells the story of that extraordinary partnership through the eyes of a modern group of female singers and musicians as they travel to Venice to recreate Vivaldi's music in the Pieta as it sounded 300 years ago.