When Carface and Killer take over the Flea Bite Cafe and turn it into a video game arcade, Charlie and Itchy have to dress up like girls to get the cafe back! But will their diguises work?
When Charlie and Itchy get into an arguement, Anabelle decides to take Itchy's place on their next mission! But when their mission gets them sent to the pound, will Charlie admit that he needs Itchy's help?
A new Guardian Angel, named Lance, comes to town, with more heroism and bravery than Charlie and Itchy. Did Anabelle send this new dog to take over their jobs?!
Annabelle gives Charlie and Itchy the assignment to find a home for a little puppy, although Charlie does mess up her signal on the receiving end. The puppy turns out to be extremely wild and impossible to find a home. However, Charlie figures out that Sasha gets all goo-goo eyed when she sees how sensative he is to take care of a puppy.
Itchy is unable to properly beg for food, unlike Charlie, who masters it quite often. Under Charlie's guidance, Itchy begs a rich kid for ice cream, who, in return, takes Itchy as a new pet. Charlie successfully rescues Itchy from the clutches of the kid, but Itchy refuses to leave and tells Charlie that the kid is lonely and they must help her make friends. Meanwhile, Carface and Killer have picked the same house as their next target in a string of burglaries.
Itchy falls in love with a dog named Bess! But when Bess is convinced that Charlie loves her, will Charlie and Itchy's friendship be broken?
David receives a voice recorder on his birthday, as Charlie and Itchy bump into him with it on the streets the following morning. However, David shows off his new gadget in school, and ends up receiving detention. Charlie, who never had a birthday of his own due to him being a street dog, wants to give David a great birthday. Using David's new voice recorder, Charlie creates an impromptu David look-alike with the voice recorder repeatedly saying mathematical equations and sneaks him out of detention.
Carface and Killer steal Itchy's Heavenly Collar, so Charlie, Itchy and Sasha plan to get it back! But when the plan involves Sasha seducing Carface, will Charlie's jealousy flub the whole plan up?
Bess and Sasha meet for the first time, and decide to plan a double date with Charlie and Itchy in order for the two to stop fighting. But the problem they don't know is that Anabelle switched Charlie and Itchy's personality souls into each other's bodies. Charlie is in Itchy's body, and Itchy is in Charlie's body and it becomes worse.
Sasha leaves town and leaves Charlie and Itchy in charge of the Flea Bite until she returns. All goes well at first, but with an evil money-stealing scheme from Carface and Killer around the corner, will Charlie end up losing the Cafe's money?
Charlie auditions to be the new spokesdog for Gulpo Dog Food, but the advertising company picks Itchy instead. Now Itchy is famous and Charlie is left wailing his woes in the Flea Bite Cafe, will Charlie lose his best friend?
Charlie and Itchy are assigned to help a boy who wants to join a baseball team. But if they succeed, Itchy is going to move back into Heaven! With the seperation between him and his best friend at hand, will Charlie screw up the mission on purpose? Or will he help out and let Itchy go back to Heaven?
Sasha wants the perfect dog, and Charlie's gonna give him to her... by pretending to have amnesia and smothering her with love and kindness of course! Will Sasha drown in the affection, or will she find out and fight back?
Anabelle's latest mission sounds very suspicious... and something's not right. Did Anabelle get her fur dyed purple? No, it's Belladonna, Anabelle's evil cousin who works for the ""other side""! And with a little sweet talk, she coaxes Charlie to join her! Will Charlie really betray Itchy, Anabelle, and all of the good dogs on Earth and Heaven just for free food?!
Charlie is dog-tired and needs a vacation. Which is exactly what he manages to convince Itchy into taking. But with so many bad things happening in the city today, Charlie can't even go a block without being someone's Guardian Angel! Will Charlie finally leave the city for a while?
Charlie and Itchy are assigned to return a cat named Dilly to her owner. But when Dilly gets taken in by a dog-hating old lady, Charlie and Itchy must use a Miracle Dog Tag to become cats to rescue her!
Charlie seems to have overbooked his schedule between a fight with Otto's gang, his Poker buds, and having lunch with Sasha! Charlie's worried, until he, Itchy, and David find a magic multiplying box, that he uses to clone himself to make each appointment! Now Charlie is in triple trouble when each of his clones mess up in their own way during each appointment, ultimately leaving the real Charlie to confront his friends, enemies, and Sasha! Oh, Charlie, what are you going to do?!
Charlie volunteers to go get notes that David's crush, Alex, left in her mom's car, but Sasha must go with Charlie instead of Itchy because he's sick from running around in the rain! Unfortunately, Charlie doesn't see women as good partners for this type of thing... looks like it's time for Sasha to show Charlie just what women can do!
Bess is being threatened by Manfred and wants out of the relationship to be with Itchy. Itchy tries everything to protect her as Manfred makes fun, but Charlie saves Bess from being hurt by Manfred. Itchy is later hypnotized by a magician who turns him into a superhero.
Charlie and Itchy are watching a wilderness movie, and Itchy becomes frightened. Charlie tells Itchy that every dog has got wolf blood in them, even Itchy. Charlie then decides that they are going on a trip into the wild, so Itchy can live up to his heritage.
Charlie's competative side shows when the new board game Kibbleland hits the streets. When it comes to games, Charlie is selfish and only thinks about himself and how to win. This becomes a problem when Belladonna tricks Sasha into playing with a magical game piece and sucking her into a world of snake-like bacon and karate pork chops! Charlie and Itchy have to save her... if Charlie can think about anyone but himself, that is!
Anabelle tells Itchy and Charlie to guard a "crystal". Charlie and Itchy have been playing pranks. Charlie thinks he sees a UFO and tells Itchy. Itchy thinks it's just another prank, and leaves. Then the "aliens" come into Itchy and Charlie's home, and scare Charlie away. The "aliens" were actually Carface and Killer. When Charlie finds this out, he plots a scheme to get them back and the "crystal".
Itchy gets sent to the pound and has to break out with help from Killer. Can the two work together and get out?
Charlie has been lying a bit too much lately, so Anabelle makes his nose grow every time he tells a lie. Will Charlie start telling the truth, or face the consequences?
Charlie has a dream of him becoming a detective to find out about a cat-scheme back in the 1930s.
The next mission for Charlie and Itchy takes them to the sewers to help a colony of mice. Toxic smelling paint and other junk are washed down the drains, taking away their freedom of living without anything to worry about. Charlie and Itchy team up with Moxie, a mother mouse in the colony, to crack the case. They follow the drain to Carface and Killer's curio shop, trying to transform new looking toy trains to look like antiques to sell for loads of money. The problem is almost unbearable for Charlie to succeed in, until Anabelle tells him that the pollution in the water would someday end up in his dish.
Charlie's little advice to Itchy ""Be a phoney to impress a phoney"" and ""Show dogs never itch in public"" makes Bess' reunion turn to disaster. Itchy, hiding the fact that he was a street dog, escorts Bess to her dog school reunion. All the dogs attending were high-horsed snobs, especially the Afghan Hound Tiffany. When she put down Bess, Charlie convinced Itchy for revenge. Prank after prank, nothing was resolved but a big mess for the spaniel to clean up. After Tiffany secretly put fleas on Itchy, the beam she was standing on was collapsing. With the other dogs not willing to help, it was Itchy to the rescue. After he got her down, the Afghan admited she was wrong, and appologised to Itchy and Bess. No RECAP yet
When a casino owning dog named Charlie is murdered by his rival Carface, he finds himself in Heaven basically by default since all dogs go to heaven. However, since he wants to get back at his killer, he cons his way back to the living with the warning that doing that damns him to Hell. Once back, he teams with his old partner, Itchy to prep his retaliation. He also stumbles on to an orphan girl who can talk to the animals, thus allowing him to get the inside info on the races to ensure his wins to finance his plans. However, all the while, he is still haunted by nightmares on what's waiting for him on the other side unless he can prove that he is worthy of Heaven again.
Charlie and Itchy return to Earth to find Gabriel's Horn, but along the way meet up with a young boy named David, who ran away from home.
Charlie B. Barker and Itchy Ford are back with Sasha and the gang having a Dicken's of a time as they try to save Christmas from Carface and an evil spirit that wishes to use dogs all over the world to ruin Christmas forever.