Throughout the centuries, psychoactive cacti, like peyote and huachuma, guided our ancestors on a sacred path of healing and spiritual transformation. Our team of explorers discuss the ceremonial use of cacti in the Americas since ancient times and what this psychoactive plant holds for our future. Clinicians and healers have discovered that cacti open the frontal context to help us think clearly and enable them to detect energy patterns in the body which may indicate disease.