| Name | Type | Role | |
|---|---|---|---|
| Bae Joo-hyun | Musical Guest | Red Velvet - Irene | |
| Yoon Ji-sung | Musical Guest | Wanna One - Jisung | |
| Park Woo-jin | Musical Guest | Wanna One - Woojin | |
| Sehun | Musical Guest | EXO - Sehun | |
| Park Ji-hyo | Musical Guest | Twice - Jihyo | |
| Woo Ji-yoon | Musical Guest | Bolbbalgan4 - Jiyoon | |
| Kim Ye-won | Musical Guest | GFriend - Umji | |
| Kai | Musical Guest | EXO - Kai | |
| Chou Tzuyu | Musical Guest | Twice - Tzuyu | |
| IU | Musical Guest | IU | |
| Xiumin | Musical Guest | EXO - Xiumin | |
| Kim Jae-hwan | Musical Guest | Wanna One - Jaehwan | |
| Jung Ye-rin | Musical Guest | GFriend - Yerin | |
| Kim Da-hyun | Musical Guest | Twice - Dahyun | |
| Hong Jin-young | Musical Guest | Hong Jin-young | |
| Yoo Jeong-yeon | Musical Guest | Twice - Jeongyeon | |
| Kim Jin-woo | Musical Guest | Winner - Jinwoo | |
| Bae Jin-young | Musical Guest | Wanna One - Jinyoung | |
| Kang Seul-gi | Musical Guest | Red Velvet - Seulgi | |
| Ong Seong-wu | Musical Guest | Wanna One - Seongwu | |
| BTS | Musical Guest | ||
| RM | Musical Guest | BTS - RM | |
| Park Hyo-shin | Musical Guest | Park Hyo-shin | |
| Lai Guanlin | Musical Guest | Wanna One - Kuanlin | |
| Chen | Musical Guest | EXO - Chen | |
| Jung Eun-bi | Musical Guest | GFriend - Eunha | |
| Park Soo-young | Musical Guest | Red Velvet - Joy | |
| Park Ji-hoon | Musical Guest | Wanna One - Jihoon | |
| Kang Seung-yoon | Musical Guest | Winner - Seungyoon | |
| Hirai Momo | Musical Guest | Twice - Momo | |
| Jimin | Musical Guest | BTS - Jimin | |
| j-hope | Musical Guest | BTS - J-Hope | |
| Lay Zhang | Musical Guest | EXO - Lay | |
| Jin | Musical Guest | BTS - Jin | |
| Ha Sung-woon | Musical Guest | Wanna One - Sungwoon | |
| Hwang Min-hyun | Musical Guest | Wanna One - Minhyun | |
| Suho | Musical Guest | EXO - Suho | |
| Choi Yu-na | Musical Guest | GFriend - Yuju | |
| Kim Ye-rim | Musical Guest | Red Velvet - Yeri | |
| Kim Young-chul | Musical Guest | Kim Young-chul | |
| Myoui Mina | Musical Guest | Twice - Mina | |
| Lee Seung-hoon | Musical Guest | Winner - Seunghoon | |
| V | Musical Guest | BTS - V | |
| Lee Dae-hwi | Musical Guest | Wanna One - Daehwi | |
| Son Seung-wan | Musical Guest | Red Velvet - Wendy | |
| Kim So-jung | Musical Guest | GFriend - Sowon | |
| Song Min-ho | Musical Guest | Winner - Mino | |
| SUGA | Musical Guest | BTS - Suga | |
| Chanyeol | Musical Guest | EXO - Chanyeol | |
| Baekhyun | Musical Guest | EXO - Baekhyun | |
| Hwang Eun-bi | Musical Guest | GFriend - SinB | |
| Ahn Ji-young | Musical Guest | Bolbbalgan4 - Jiyoung | |
| Doh Kyung-soo | Musical Guest | EXO - D.O. | |
| Son Chae-young | Musical Guest | Twice - Chaeyoung | |
| Kim Hyun-ah | Musical Guest | Hyuna | |
| Jung Kook | Musical Guest | BTS - Jungkook | |
| Kang Daniel | Musical Guest | Wanna One - Daniel | |
| Seol In-ah | Guest Star | Presenter for MBC Music Star Award and Best Rap/Hip Hop | |
| Song Seung-heon | Guest Star | Presenter for Album of the Year (Daesang) | |
| Yoo Jae-hwan | Guest Star | Presenter for Best Songwriter Award and Hot Trend Award | |
| Bae Jung-Nam | Guest Star | Presenter for Best Indie and Best R&B/Soul | |
| Im Na-yeon | Guest Star | Twice-Nayeon | |
| Kim So-hyun | Guest Star | Presenter for Top 10 Artists (Wanna One) and Stage of the Year | |
| Daniel Lindemann | Guest Star | Presenter for Kakao Hot Star Award | |
| Yeo Jin-goo | Guest Star | Presenter for Top 10 Artists (Twice and Bolbbalgan4) | |
| Kim Eugene | Guest Star | Presenter for Song of the Year (Daesang) | |
| Ahn Hyo-seop | Guest Star | Presenter for Best of Dance Performance | |
| Kang Han-na | Guest Star | Presenter for Top 10 Artists (Heize and IU) | |
| Song Jae-rim | Guest Star | Presenter for 1theK Performance Award and Netizen Popularity Award | |
| Alberto Mondi | Guest Star | Presenter for Kakao Hot Star Award | |
| Tony Ahn | Guest Star | Presenter for Best New Artists | |
| Jung Woo-sung | Guest Star | Presenter for Artist of the Year (Daesang) | |
| Park Ha-na | Guest Star | Presenter for Top 10 Artists (Red Velvet and Winner) | |
| Kang Seung-hyun | Guest Star | Presenter for Best of Dance Performance | |
| Hong Yun-hwa | Guest Star | Presenter for Best Folk/Blues and Best Trot | |
| Jang Shin-young | Guest Star | Presenter for 1theK Performance Award and Netizen Popularity Award | |
| Guillaume Patry | Guest Star | Presenter for Kakao Hot Star Award | |
| Hong Jong-hyun | Guest Star | Presenter for Top 10 Artists (BTS and EXO) | |
| Minatozaki Sana | Guest Star | Twice-Sana | |
| Kim Poong | Guest Star | Presenter for Best OST and Best Music Video | |
| Kim Joon-hyun | Guest Star | Presenter for MBC Music Star Award and Best Rap/Hip Hop | |
| Han Hyun-min | Guest Star | Presenter for Global Artist | |
| Baek Ji-young | Guest Star | Presenter for Best Songwriter Award and Hot Trend Award | |
| Han Da-gam | Guest Star | Presenter for Top 10 Artists (BTS and EXO) | |
| Im Na-yeon | Guest Star | ||
| Park Kyeong-rim | Guest Star | Presenter for Best OST and Best Music Video |