The episode follows three stories of people whose lives have been remarkably changed due to unforeseen circumstances. 46-year-old Claire has been sent to A&E by her GP with chronic back pain. Doctors are concerned she may be suffering a serious underlying spinal injury. Claire talks bravely about the life changing moment her sister passed away and the implications for her family. 44-year-old Anne Marie has been rushed to St George’s with a suspected stroke. Doctors have to act quickly to help prevent any long-lasting damage. Her best friend Tunji recalls the medical difficulties Anne Marie has had to overcome throughout her life. New born Gracie has been brought to St George’s paediatric department by new parents Danny and Jordan concerned she has an infected umbilical cord. Gracie’s parents discuss the life changes and joy of becoming parents for the first time.