The film starts with a voice-over of Jane Goodale (Ashley Judd) over the images of a scientific experiment with a bull and a herd of cows, apparently the bull never mounts a cow twice, not even if her scent is changed. He prefers a new cow. Jane says that until recently, she believed that men are all like the bull, but to understand what happened we have to go back in time. Jane is a production assistant with a talk show that has recently been syndicated, which means that the host Diane Roberts (Ellen Barkin) who wants to be the best, is always looking for the ungettable guests, like Fidel Castro. Eddie Alden (Hugh Jackman) is the producer of the talk show and is a womanizer, much to the dismay of Jane who comments on his actions with amicable critique.
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