On June 21, 2028, a riot breaks out in Los Angeles over the city's water privatization. Taking advantage of the chaos, professional criminal Sherman attempts a bank robbery that leaves his brother Lev and another accomplice critically wounded. They escape to the nearby Hotel Artemis, a secretive hospital that only treats criminals, run by Jean "the Nurse" Thomas. Confined inside the Hotel for 22 years by her severe agoraphobia and grief over the death of her son, Thomas adheres to a strict set of rules, including "No weapons," "No non-members," and "No killing of other guests."
Nel 2028, mentre Los Angeles è ormai in preda a una violenta rivolta, un trafficante d'armi, un assassino francese, dei ladri e un poliziotto ferito si fanno strada verso l'Hotel Artemis, un ospedale privato per soli criminali.
Dans un futur proche, une infirmière, qui dirige un hôpital regroupant les plus dangereux criminels de Los Angeles, découvre que l'un de ses patients est dans l'établissement afin d'en assassiner un autre.
Los Ángeles, año 2028. El Hotel Artemis es un hospital exclusivo para delincuentes, regentado por Jean Thomas y ceñido a unas reglas muy estrictas. Cuando el centro es atacado, dará paso a una espiral de violencia difícil de contener.
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