小松左京の同名SF小説を原作に、要人暗殺を企む悪の超能力集団と、超能力を持つ諜報員・エスパイ（エスパー+スパイ）のサイキック合戦を描く。アクション映画を得意とする監督・福田純と「日本沈没」のＳＦＸ担当・中野昭慶のコンビが放つＳＦ活劇。田村、マリア、三木の3人は、国連の秘密組織'“エスパイ”で働いていた。エスパイとは、超能力を悪用する逆エスパイと戦うための超能力者を養成する機関である。世界各地でVIPの暗殺事件が続発し、やがて、東西冷戦の要・バルトニアの首相暗殺計画をめぐって３人の活躍が始まる・・・。
The International Psychic Power Group is a covert organization financed by the United Nations. Made up of clairvoyant supermen under the guise of the International Pollution Research Center, they wage a private war against enemies that threaten world peace and the total annihilation of the human race. With hostility between the East and West reaching a boiling point, four Eastern European delegates are assassinated aboard the Milan-Geneva International Express on their way to the United Nations for the Mediation Committee of International Dispute. The Baltonian Prime Minister is the next to be targeted for termination. A ruthless psychic assassin named Goro hunts down the psychokinetic saviors, themselves marked for death by an anti-ESPY group led by the insidious and superhuman Ulrov, who plans to destroy mankind by initiating World War III.
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