Chev Chelios (Jason Statham) lands in the middle of an intersection after Crank (film) He is scooped off the street by gangsters and removed from the scene. Chev wakes up in a makeshift hospital and sees doctors removing his heart while Johnny Vang (Art Hsu) watches. The doctors place an artificial heart in his chest. He wakes up later and escapes, noticing an external battery pack is attached to him. After interrogating a thug, he learns the location of Johnny Vang: the Cypress Social Club.
A British hitman living in LA is poisoned with the Beijing Cocktail which blocks the adrenal gland. To survive he must keep a constant flow of adrenalin coursing through his body while finding the cure and his would-be killers.
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