The films follow the events that unfold at schools in Tromaville, New Jersey, which are conveniently located next to a nuclear power plant.
The film follows the events that unfold at Tromaville High School in New Jersey, which is conveniently located next to a nuclear power plant. An accident at the nuclear plant is covered up by plant owner Mr Paley who does not want the facility shut down by the safety commission. The accident causes a radioactive water leak which ends up gruesomely killing a student at the school after the tainted water reaches the drinking fountain. The gang of the school, called "The Cretins," who were originally part of the honor society, torments the school, and it's implied that they have been turned into violent psychopaths by the runoff from the plant. They pick leaves from a radioactive marijuana plant located in the yard of the nuclear plant and sell it to Eddie for $10. At his "indoor bikini beach party" that night, Eddie pressures his friend Warren and Warren's girlfriend Chrissy into smoking the radioactive joint, but it is accidentally ruined by the dancers before anyone else can try it. The mutated drug shows itself to have potent aphrodisiac effects, leading to Warren and Chrissy having sex in Eddie's loft. However, that same night, both of them have disturbing nightmares about hideously mutating, though these effects are seemingly gone by morning. Some time later, Chrissy discovers that she is pregnant, and spits a little monster into a nearby toilet. The creature travels through the water pipes and lands in a barrel filled with radioactive waste, and mutates into a bigger creature. Meanwhile, Warren, tired of the Cretins' constant harassment, ends up going on a radiation-fueled rampage, killing two of them, with no memory of the event once he comes to his senses. The Cretins, expelled from the school and cut off from their customer base, assault the principal and forces him to use the school's Radiation Alarm to cause an evacuation, letting the Cretins bar the building and occupy it. Capturing Chrissy as bait for Warren, the leader of the gang holds her hostage in th
Tromaville's nuclear reactor has been rebuilt and the Nukamama Corporation that funded it has incorporated a new college, the Tromaville Institute of Technology (T.I.T.), inside the design, as an effort to atone for the events of the first film. Located inside the nuclear plant, is where Professor Holt who has perfected a race of 'Sub-humanoids'; Living beings without emotions, who have been created and programmed to perform menial tasks. When school reporter Roger Smith meets a beautiful subhumanoid named Victoria, they fall in love. However, the creatures have a tendency to go into spontaneous meltdown. Roger is now determined to save Victoria from this messy fate, but first he'll have to face the giant mutant squirrel, Tromie, who attacks Tromaville tech in the climax.
Moments after the end of Class of Nuke 'Em High 2: Subhumanoid Meltdown, the mutant squirrel Tromie is subdued and life in Tromaville returns to normal. Roger Smith, now mayor of Tromaville, is overjoyed at the birth of his twin sons, Dick and Adlai. Unfortunately for all concerned parties, Dick is kidnapped at the hospital and subsequently raised to be evil by the thugs who took him. Adlai, meanwhile, is raised by Roger to be kind and peaceful.
In Tromaville High School the glee club has mutated into a vicious gang called The Cretins. Chrissy and Lauren, two innocent bloggers, must fight not only the Cretins, mutants and monsters but also the evil Tromorganic Foodstuffs Conglomerate.
