FBI agent Malcolm Turner is tough, smart and a master of disguise. Taking on his most challenging "role" ever, Malcolm decides to impersonate the cantankerous Southern granny Big Momma, even taking on her everyday routine — from cooking soul food to delivering babies to "testifying" at the local church.
Six years after the events of the first film, Malcolm Turner (Martin Lawrence) has been assigned a desk job in public relations as an Federal Bureau of Investigation agent, since he wants to live with his wife, Sherry Pierce (Nia Long), during her delivery for the couple's new baby boy. Meanwhile, an incident occurs in Orange County, California, where Malcolm's old friend, Doug Hudson (Kirk B.R. Woller), has been killed while he was going undercover.
Federal Bureau of Investigation agent Malcolm Turner is elated to learn that his stepson, Trent Pierce, has been accepted to attend Duke University in Durham, North Carolina. However, Trent is uninterested and instead wants Malcolm to sign a recording contract for him since he is underage. When Malcolm refuses, Trent's best friends encourage him to ambush Malcolm on the job in order to obtain the signature.