A pampered Beverly Hills Chihuahua named Chloe finds herself accidentally lost in the mean streets of Mexico without a day spa or Rodeo Drive boutique anywhere in sight. Now alone for the first time in her spoiled life, she must rely on some unexpected friends, including a street-hardened German Shepherd named Delgado and an amorous pup named Papi, to lend her a paw and help her to find her inner strength on their incredible journey back home.
The five rambunctious, mischievous puppies of Chihuahuas Papi and Chloe present one challenge after another. But when their human owners end up in trouble, the tiny pups will stop at nothing to save them, because in good times and hard times, the family always sticks together.