Six years after their Guantanamo Bay adventure, stoner buds Harold Lee and Kumar Patel cause a holiday fracas by inadvertently burning down Harold's father-in-law's prize Christmas tree.
After being mistaken for terrorists and thrown into Guantánamo Bay, stoners Harold and Kumar escape and return to the U.S., where they proceed to flee across the country with federal agents in hot pursuit.
A Korean-American office worker and his Indian-American stoner friend embark on a quest to satisfy their desire for White Castle burgers.