The six-person crew of a derelict spaceship awakens from stasis in the farthest reaches of space. Their memories wiped clean, they have no recollection of who they are or how they got on board. The only clue to their identities is a cargo bay full of weaponry and a destination: a remote mining colony that is about to become a war zone. With no idea whose side they are on, they face a deadly decision. Will these amnesiacs turn their backs on history, or will their pasts catch up with them?
Two hundred years in the future, in a fully colonized solar system, police detective Josephus Miller is given the assignment to find a missing young woman, Julie Mao. Joining his task is James Holden, former first officer of an ice freighter who is involved in an incident caused by the tense relationship between Earth, Mars and the Belt. Far from their struggles in space, United Nations executive Chrisjen Avasarala works to prevent war between Earth and Mars. Soon the three find out that the missing woman is connected to a vast conspiracy that threatens all humanity.