Set in the fictional town of Acme Acres, the series follows the adventures of a group of young cartoon characters who attend Acme Looniversity to become the next generation of characters from Looney Tunes. The cartoon was the first animated series produced by the collaboration of Steven Spielberg's Amblin Entertainment and Warner Bros. Animation.
The ''Tiny Toon Adventures'' characters leave for their summer vacations after their term at Acme Looniversity ends. Babs and Buster Bunny have a water pistol fight, which eventually escalates into their flooding Acme Acres. The bunnies, along with List of Tiny Toon Adventures characters#Byron Basset, float from flooded Acme Acres down to the Southern United States, where they continuously avoid getting eaten by the river's residents.
The show follows the adventures of Plucky Duck, a teen-aged university student whose mentor is Daffy. Like Daffy, Plucky's exploits are often quests for fame or fortune.
Buster Bunny is trying to produce and direct the Tiny Toons Holiday Special, but it is not working. Montana max, makes him look bad, and then bribes the network executives into firing Buster and making him the producer. Buster thinks he has had it, and plans to throw himself out of cartoons forever. His guardian angel appears and shows him what Tiny Toons would be like without him.
Pinky and the Brain, those two genetically engineered lab mice, are homeless now that Acme Labs is no more. And the mice are in need of a place to hide as a secret organization wants to apprehend Brain. While hiding in a pet shop, the mice wound up getting bought by Elmyra Duff. Now the mice are forced to operate from Elmyra's house and endure her twisted ways of caring for animals. Despite all of these new complications, Pinky and the Brain still continue to try to take over the world.
Follow the Tiny Toon characters' comedic ambitions all the way to Acme Looniversity, the esteemed institution of higher high-jinks learning, where young dreamers become professional toons. Here they form long-lasting friendships with one another and perfect their cartoony craft while studying under the greatest cartoon characters in history, the Looney Tunes.
