En 2045, l'intelligence artificielle est partout. Mais quand les robots se soulèvent, Alice se retrouve enfermée chez elle… protégée par ses androïdes bien intentionnés.
Riley Andersen and her parents move from the Midwest to San Fransisco, leaving Riley to deal with some overwhelming life changes. Her emotions try to guide her from her mind's Headquarters, but Sadness keeps touching old memories which causes Riley emotional distress. The emotions, lead by Joy, try to save Riley's memories and help her find emotional stability again.