The biopic stars Rachel Weisz as Hypatia, a female mathematician, philosopher and astronomer in late 4th-century Roman Egypt, who investigates the flaws of the geocentric Ptolemaic system and the heliocentric model that challenges it. Surrounded by religious turmoil and social unrest, Hypatia struggles to save the knowledge of classical antiquity from destruction. The story uses historical fiction to highlight the relationship between religion and science at the time amidst the decline of Greco-Roman polytheism and the Christianization of the Roman Empire